Amodiaquine failure associated with erythrocytic glutathione in Plasmodium falciparum malaria
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1 Amodiaquine resistance in Plasmodium falciparum malaria is associated with 1 the pfcrt 72 - 76
Amodiaquine resistance in Plasmodium falciparum malaria is associated with 1 the pfcrt 72-76 SVMNT allele in Afghanistan 2 3 Khalid Beshir, Colin J. Sutherland, Ioannis Merinopoulos, Naeem Durrani, 4 Toby Leslie, Mark Rowland, Rachel L. Hallett * 5 6 Department of Infectious and Tropical Diseases, London School of Hygiene & 7 Tropical Medicine, London, UK. 8 Merlin International, House 3, Stree...
متن کاملModeling Combinations of Pre-erythrocytic Plasmodium falciparum Malaria Vaccines.
Despite substantial progress in the control of Plasmodium falciparum infection due to the widespread deployment of insecticide-treated bed nets and artemisinin combination therapies, malaria remains a prolific killer, with over half a million deaths estimated to have occurred in 2013 alone. Recent evidence of the development of resistance to treatments in both parasites and their mosquito vecto...
متن کاملAmodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial.
BACKGROUND Increasing drug resistance limits the choice of efficacious chemotherapy against Plasmodium falciparum malaria in Africa. Amodiaquine still retains efficacy against P falciparum in many African countries. We assessed the safety, treatment efficacy, and effect on gametocyte carriage of adding artesunate to amodiaquine in three randomised trials in Kenya, Sénégal, and Gabon. METHODS ...
متن کاملAmodiaquine resistance in Plasmodium falciparum malaria is associated with 1 the pfcrt 72 - 76 SVMNT allele in Afghanistan 2 3
Amodiaquine resistance in Plasmodium falciparum malaria is associated with 1 the pfcrt 72-76 SVMNT allele in Afghanistan 2 3 Khalid Beshir, Colin J. Sutherland, Ioannis Merinopoulos, Naeem Durrani, 4 Toby Leslie, Mark Rowland, Rachel L. Hallett * 5 6 Department of Infectious and Tropical Diseases, London School of Hygiene & 7 Tropical Medicine, London, UK. 8 Merlin International, House 3, Stree...
متن کاملThe Use of Crude Plasmodium falciparum Antigens for Comparison of Antibody Responses in Patients with Mild Malaria vs. Cerebral Malaria
Background: Cerebral malaria (CM) is one of the major causes of death in African populations infected with Plasmodium falciparum. Only 1% of infected subjects develop CM. The reasons for these differences are not fully understood, but it is likely that the host humoral response against blood-stage antigens plays a role in protection from malaria, although the precise targets and mechanisms medi...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2007
ISSN: 1475-2875
DOI: 10.1186/1475-2875-6-47